ET | CBS What to know for fantasy: Jameis Winston has thrown three-plus touchdown passes in consecutive games for the first time in his career, but now he gets a Saints team against which he has never thrown three-plus touchdown passes in a game. Since Alex Smith got injured in Week 11 of last season, it has had an NFL-high five starting QBs. Betting nugget: Atlanta has failed to cover 13 straight games against AFC opponents (1-12 outright). Listed at 5-foot-8, 187 pounds, he stood tall against Denver last week with a 68-yard scoop-and-score TD and played tough defense against Jerry Jeudy. Week 5 brings some more great matchups and potential upsets. FPI prediction: GB, 86.9% (by an average of 13.5 points), Matchup must-reads: How Saquon Barkley and AJ Dillon became the 'Quad Kings' of the NFL Landon Collins, Giants finalizing deal, sources say Packers' Aaron Rodgers wanted longer London trip Rodgers: 'This way of winning, I don't think, is sustainable', What to know for NFL Week 5: Score picks, bold predictions, fantasy tips, key stats for all 15 games, Which NFL teams still have roster holes? The Bengals as a whole have an NFL-worst 2.8 yards per rush and NFL-low 1.5 yards before first contact. He had just 14 receptions for 174 yards and zero TDs in 11 games last season. Analyzing how, where Golden Tate fits into Giants' offense, 1 p.m. 1 min read. His six catches last week against the Chargers are 60% of his grabs for the season. Legwold's pick: Chargers 23, Broncos 21 -- Marcel Louis-Jacques. The one thing that might help their offense is the return of running back Alvin Kamara, who said he's ready to roll this week. Overall, Minnesota is tied for eighth in points allowed (19.0) and third in rushing yards allowed (71.3). See Week 5 rankings. Philadelphia is allowing a league-low 4.75 yards per pass, and the Cardinals are ranked 30th in passing yards per play (5.37). He has also been sacked 11 times, tied for the eighth most in the NFL. Baby's pick: Cardinals 24, Bengals 21 Indianapolis' offensive efficiency might be a good match for Kansas City's offensive power. He is the first player with nine sacks through the first four games of a season since Kabeer Gbaja-Biamila recorded nine in 2001. Our NFL Nation reporters bring us the keys to every game, a bold prediction for each matchup and final score predictions. Vikings 27, Bears 26 -- Jeff Dickerson, Cowboys' running game will be tested on Sunday (1:06), Week 5 NFL predictions: Scores for every game, Dolphins' Jaelan Phillips, teammates inspired by mentoring incarcerated teens, What adding Odell Beckham Jr. would mean for the New York Jets, Extending Vikings star Justin Jefferson: what it could cost, possible sticking points. Washington's pass defense is allowing 259.8 yards per game, but 294 yards per game at home. The Bears, however, are the league's least-equipped team to exploit that shortcoming. -- Brooke Pryor, NFL PrimeTime continues this postseason with extended highlights and analysis following the conclusion of each day's playoff games. What to know for fantasy: Breece Hall has a touchdown or six catches in all four games this season and seems to be trending in the direction of a lineup lock. The first round of the 2023 NFL Draft certainly had its moments, as three quarterbacks went within the first four picks and each of the major conferences had a player selected for the first time . He is tied with Russell Wilson for the most in the NFL in that span. 1 overall pick, are hours away from being on the clock -- which means the 2023 NFL draft has arrived. -- Michael Rothstein. Betting nugget: This game has the highest over/under this season. To take advantage of the Ravens' weak spot, the Steelers could push Rudolph to unleash more deep throws. On the other side of the ball, Tom Brady said his shoulder is fine, but former Falcon Julio Jones' status is up in the air after missing the second half last week because of a knee injury. Read more. See Week 5 rankings. Their offense is clicking on all cylinders, and their defense finally showed signs of life in the second half Sunday, holding Dallas to a mere six points. That's tied for the most outright wins without a loss in any matchup in NFL history, according to Elias Sports Bureau research. Atlanta is the only team this season undefeated against the spread. Since the start of last season, 13 of the Bills' 20 games have gone under. -- John Keim, Bold prediction: Titans quarterback Ryan Tannehill will finish with 300 passing yards in a win over the Commanders. Matchup rating: 49.4 | Spread: LAC -6.5 (44.5), What to watch for: With Denver desperate for a win and fellow edge rusher Bradley Chubb done for the year because of an ACL injury, look for Von Miller to ignite the Broncos by getting after Philip Rivers, who has limited mobility. Barshop's pick: Texans 20, Falcons 17 Commanders patient with Wentz despite rough stretch RB Robinson returns to practice after being shot in robbery attempt, What to watch for: Texans running back Dameon Pierce is coming off the first 100-yard game of his career (which included a 75-yard TD run) and ranks 10th in the NFL in rushing. Betting nugget: Baltimore has covered each of the past five meetings in Pittsburgh. Stat to know: The Eagles' Carson Wentz has 963 passing yards on the season, and he needs 400 more to have his most through the first five games of a season in his career (his single-game career high is 364). Matchup rating: 44.9 | Spread: CHI -5 (40.5), What to watch for: Khalil Mack will be looking to take over the game against his former teammates. -- David Newton, Bold prediction: San Francisco 49ers defensive end Nick Bosa will have three sacks in his second career game against the Panthers. We answered the biggest QB questions, How Saquon Barkley and AJ Dillon became the 'Quad Kings' of the NFL, Landon Collins, Giants finalizing deal, sources say, Packers' Aaron Rodgers wanted longer London trip, Rodgers: 'This way of winning, I don't think, is sustainable', Do Not Sell or Share My Personal Information. What to know for fantasy: Pierce has more than 100 scrimmage yards and a rushing score in consecutive games. After catching eight passes for 111 yards in the season opener, he has not reached 70 receiving yards in any of the past three games. Spread: PHI -5.0 (49.5), What to watch for: The Cardinals will have their work cut out for them passing and defending the ball. Watch on ESPN+ More , Bold prediction: Nope. -- Turron Davenport, Bold prediction: The Bills, who possess the NFL's fourth-best rushing attack in terms of yards per game, will run for at least 150 yards against a Titans defense that has given up a combined 146 rushing yards over its past two games. Including playoffs, Rodgers has thrown 29 touchdown passes with just eight interceptions in 15 games. Raiders hoping to reverse London trend by changing travel schedule Left with no defense, Jackson needs to carry Ravens this season, 1 p.m. FPI prediction: NO, 72.6% (by an average of 6.9 points), Matchup must-reads: The Seahawks have needed every bit of Geno Smith's unlikely success Andy Dalton gave Saints' offense a spark, but bigger issues loom after 1-3 start Saints' Alvin Kamara (rib) expects to play against Seahawks, What to watch for: Washington has done a nice job stopping the run the past two weeks against the Eagles and Cowboys, allowing an NFL-best 2.27 yards per carry and tying for second at 67 yards allowed during that stretch. Super Bowl champs ready for the draft Cimini's pick: Eagles 27, Jets 9 Last week, we hit the Falcons at +3. See Week 5 rankings. . -- Jenna Laine, Bold prediction: The Falcons, with no Cordarrelle Patterson and against a good run defense, will manage to once again top 150 rushing yards with Tyler Allgeier leading the way. While the Chargers' running game has struggled, Herbert will always be a threat in the passing game. What to know for fantasy: Murray leads the NFL with 187 opportunities this season (pass-plus-rush attempts). McManus' pick: Steelers 24 . Additionally, the Eagles are averaging a league-high 8.79 passing yards per play while the Cardinals are giving up 7.36, which ranks 25th in the league. 1, Panthers' Bryce Young is all 'business now', Top picks Christian Gonzalez, Keion White reflect Patriots' ideal identity, Big takeaways from the NFL draft: A historic QB class, the rebuilt AFC South and new GMs thriving, NFL Nation sizes up all 259 draft selections, XFL semifinals: Defenders roll Sea Dragons, set up title showdown with Renegades. But the Commanders' run defense will be severely tested by Tennessee running back Derrick Henry. Packers 33, Cowboys 27 -- Todd Archer, The Chiefs are 8-1 against quarterbacks in their first season as starters since Andy Reid arrived as head coach and Bob Sutton as defensive coordinator in 2013. Watch on ESPN+, Bold prediction: Ravens rookie receiver Marquise Brown gets back on track after two lackluster games with 100 yards receiving and two long touchdown catches. -- DJ Bien-Aime. -- Rob Demovsky. Last year alone, Mahomes threw seven touchdowns with no interceptions in two games as the Chiefs scored a combined 89 points. -- Vaughn McClure. Chicago head coach Matt Nagy is high on veteran backup quarterback Chase Daniel, who's starting in place of Mitchell Trubisky (left shoulder), but Nagy still wants to control the clock and pound the ball with Montgomery. Jump to a matchup: See Week 5 rankings. Keim's pick: Patriots 27, Redskins 7 Read more. What to know for fantasy: The Raiders' Tyrell Williams is the only player with a touchdown reception in all four weeks thus far and has seen five of Oakland's six end zone targets this season. I tweaked my predictions from Sunday to reflect . That'll help the Texans continue their eight-game winning streak over the Jaguars. -- Ben Baby. He will find a way to connect with a receiver group that will be missing first-round pick Treylon Burks. -- Tim McManus. (1 . Tannehill had only two 300-yard passing games last season and has yet to have one this year. Let's get into the full Week 5 slate, including another London showdown (Giants-Packers), Kenny Pickett's first start, Jalen Hurts vs. Kyler Murray and an AFC North meeting between the Bengals and Ravens. But theyll defeat him as they have other young quarterbacks except for Oaklands Derek Carr as a rookie in 2014. Around The NFL Podcast Co-Host. Yes, he's 2-0, but the Saints will need more from Bridgewater, 1 p.m. The Cards are dead last in the league with four sacks entering Week 5. Expect the Raiders' overachieving defense to make a play or two -- paging Khalil Mack and his four sacks -- to jump-start the offense, and all will be right in Silver and Blackdom for a week, at least. Read more. Steelers 24, Jaguars 10 -- Mike DiRocco, The Steelers' offense is poised to break out eventually; Ben Roethlisberger has only one completion of more than 40 yards this season -- which came in Week 2, his only home game. Big Ben's 3-1 home-away touchdown ratio since 2015 looms large here, especially with Bell looking like his 2016 self and Jacksonville entering the week allowing 5.7 yards per carry, the league's worst by a large margin. They also rank No. Game of Midweek: Colts at Broncos (-3.5, 44 o/u) . The Colts' three losses have come to the same three teams that San Francisco has lost to -- Arizona, Los Angeles Rams and Seattle -- and Indianapolis lost those games by a combined 68 points. Among those players, no one is averaging fewer fantasy points per touch than Sony Michel (0.44). For context, 5.2 yards per rush with McCoy on the field would rank fifth in the NFL among all teams this season, as opposed to 27th when McCoy isn't on the field. Stat to know: Daniel Jones needs two passing touchdowns and 72 passing yards to have the most in each category by a Giants quarterback in his first three NFL starts since the 1970 merger. Through the first four games, the Giants have played three starting offensive line combinations up front. The Bills' offense -- which has gone three-and-out on 48 percent of drives this season, second most in the NFL -- will be playing short-handed at wide receiver because of a thumb injury to No. Which QB will Colts take in Round 1? The Colts, meanwhile, are scoring on 40% of their possessions, 11th best. There have been 45 Longhorns selected in the first round. Stat to know: The 49ers are 0-2 and averaging 10.0 points per game on the road this season -- and 2-0, 25.5 PPG at home. Most important, Rodgers is 13-2 in those games, dating back to 2008. Read more. Stat to know: Chiefs running back LeSean McCoy has three scrimmage touchdowns this season, matching his total in 14 games last season. ESPN. NFL picks against the spread for Week 5. Our experts share their favorite upset picks for Week 5, including an unsuspecting team who is 3-1 to start the year. Dolphins 19, Titans 17 -- Cameron Wolfe, The Dolphins allowed 235 rushing yards in last year's loss to the Titans. McClure's pick: Texans 24, Falcons 21 They're tied for fourth with 25 explosive pass plays (16-plus yards), and Miami's banged-up secondary is giving up huge chunks in the passing game (31st in yards). It won't hold, though, as J.J. Watt & Co. make life miserable for the Falcons' offensive line. The Raiders . Moody's pick: Jaguars 34, Texans 14 The last thing the Vikings need is for Diggs' situation to blow up into a full-blown distraction. . Betting nugget: All four Bills games have gone under the total this season. Tennessee adopted a quick-hitting passing attack last week to speed up Mariota's decision-making, which should be the way to go against a Bills defense that takes away the vertical passing game and is third in the league in allowing a 57.1 completion percentage. -- Lindsey Thiry. Betting nugget: Smith is 23-15 ATS in his career, including 10-2 ATS in his past 12 starts and 5-2 ATS with Seattle. Walder's pick: Eagles 23, Cardinals 20 Wentz's seven picks are the most in the NFL. 3 all-time rusher Barry Sanders, Meet Brady's most trusted teammate: His 1995 shoulder pads, Redskins' January decision to maintain status quo looks bad in hindsight, Patriots' offense searching for identity, as it did in 2018, Big pass plays tearing up Ravens' defense, 'Do whatever' to win: Steelers bring back the Wildcat, Raiders hoping to reverse London trend by changing travel schedule, Left with no defense, Jackson needs to carry Ravens this season, Steelers' first draft by Khan 'aggressive', Mack expected to be with the Raiders 'for the long haul', Daniel embraces seldom-used, uncertain backup QB life, Carr: Burfict's 'heart is broken;' QB says ban isn't fair, Analyzing how, where Golden Tate fits into Giants' offense. Rodgers hasn't topped 255 yards passing this season, and the Giants have the eighth-ranked pass defense. Watch the latest episode, Bold prediction: Cleveland running back Nick Chubb rushes for more than 100 yards against San Francisco's No. Betting nugget: In the past six London games, favorites are 5-1 ATS, and five of the six games went under the total. Additionally, ESPN Stats & Information provides a big stat to know and a betting nugget for each contest, and our Football Power Index (FPI) goes inside the numbers with a matchup rating (on a scale of 1 to 100) and a game projection. -- Eric D. Williams, Bold prediction: The Broncos have not intercepted a pass this season, but they will get their first one Sunday. What to know for fantasy: With two games of seven-plus targets already this season, plus a TD reception in Week 4, Bengals tight end Hayden Hurst has potential. Read more. Cronin's pick: Giants 21, Vikings 17 -- John Keim, Bold prediction: New England running back James White will score two touchdowns, with his playing time rising because he's a top pass protector and the Redskins are a heavy blitz team. Full list of Mr. Irrelevants in NFL draft history: Is Brock Purdy already the best final pick? Steelers 27, Jaguars 20 -- Jeremy Fowler, The Seahawks are coming off one of the more dominant halves of football they've played under Pete Carroll, outscoring the Colts 36-3 and holding them to 32 yards in the second half last week. Victor Cruz contends that Gardner Minshew is better equipped to lead his team to victory in the matchup with Panthers QB Kyle Allen. This scheme has not changed and is bolstered on the back end by Eddie Jackson, who leads the NFC in interceptions with three in four games. Stat to know: Geno Smith has a 77.3 completion percentage this season, the highest by any QB through a team's first four games of a season in NFL history (min. Stat to know: Joe Burrow has 12 touchdowns on passes of 20-plus yards downfield since the start of last season. The 2023 NFL Draft continues today in Kansas City! See Week 5 rankings. -- Brady Henderson. Injuries: Eagles | Steelers. Facebook; Twitter; Facebook Messenger; Pinterest; Email; Scoring is up across the NFL. ), Jump to a matchup: NFL picks, predictions for Week 5 Los Angeles Rams (-1.5) at Seattle Seahawks Thursday, 8:20 p.m., FOX/NFL Network The NFC West grinder continues. So this is a game the Chargers normally would lose, which is why Im picking them to win -- along with the fact that I believe the Giants will have trouble stopping the Bolts talented pass-rushing duo of Melvin Ingram and Joey Bosa. Buffalo is at least a three-point underdog on the road, suggesting this could be a trap game for the Bills after big wins over Denver and Atlanta. See Week 5 rankings. They will welcome back Taylor Lewan from a four-game suspension with open arms. Cowboys 27, Packers 23 -- Rob Demovsky, For the second consecutive week, the Cowboys are facing a team with a 10-day break. Giants 24, Chargers 23 -- Jordan Raanan, The Cardinals are 0-2 this season against NFC teams not in their division, but the biggest question mark will be whether the Cardinals can keep Carson Palmer on his feet. Paired with fellow receivers John Brown and Jaron Brown, the Arizona wideouts pose a threat to a vulnerable Eagles cornerback group. The Cardinals have allowed a league-high 20 sacks; the Bengals are right behind them at 19. -- Jake Trotter. These two teams just played each other in the regular season finale last week when the Roughnecks won 25-9 despite Brandon Silvers, Max Borghi, Deontay Burnett, and Brycen Alleyne all sitting. ARI-CIN | DEN-LAC | GB-DAL Prediction: Cowboys 28, Giants 17. Los Angeles Chargers at New Orleans Saints. Commanders WR Curtis Samuel has 26 receptions this season, tied with Travis Kelce and Davante Adams for eighth most in the NFL. The Eagles' pass defense is vulnerable, but Luke Falk -- a dink-and-dunk passer -- doesn't have enough arm to exploit the matchup. This has the makings of another close loss. Irrelevant' pick on Toledo's Johnson, Chargers go all-in on TCU with Duggan pick in 7th, 10 fantasy football breakout players for 2023, Will Levis opens up about emotional draft day, Steelers' first draft under Omar Khan was 'aggressive' and achieved high marks, After hoopla of going No. CFB: The way-too-early top 25 for 2021 The Pats are coming off a 16-point performance in which quarterback Tom Brady completed just 18 of 39 passes for 150 yards and an interception. FPI prediction: JAX, 71.8% (by an average of 6.6 points), Matchup must-reads: Texans release starting TE Pharaoh Brown After loss, the Jaguars look to rebound against AFC South How LSU and the SEC prepared Texans rookie Derek Stingley Jr. for the NFL Former Jaguars QB Blake Bortles says he 'quietly' retired, What to watch for: Things have not being going well for Baker Mayfield. -- Mike Reiss. They're catching the Eagles' normally dominant offense at the right time, with left tackle Jordan Mailata (shoulder) and right guard Isaac Seumalo (ankle) dealing with injuries. Chuck Pagano has never started a season 1-4 as coach of the Colts. See Week 5 rankings. Betting nugget: Bridgewater is 25-7 against the spread (ATS) in his career as a starting quarterback, the best mark by any QB with at least 15 starts in the Super Bowl era. FPI prediction: HOU, 64.0% (by an average of 5.0 points), Matchup must-reads: How Watson's 'NFL experience' began as ball boy for the Falcons TE Hooper could be the next Falcon to cash in Quinn not worried about job, his staff, 1 p.m. If the Jaguars have the same kind of issues along the defensive front they did last week, it'll be another long day. He will etch his name in the record books, joining Jim Brown in 1958 as the second player in league history to score multiple touchdowns in four of the team's first five games. Cardinals 30, Eagles 27 -- Tim McManus, It's hard to know what the Jaguars are going to get from QB Blake Bortles each week, and this week may be even more of a mystery because the Jaguars may be without WR Marqise Lee because of a rib injury. Trevor Lawrence: Jaguars have confidence, motivation for 2023 season, Steelers work to keep playoff hopes, Mike Tomlin's streak alive, Las Vegas Raiders' defensive tackles key in allowing edge rushers Maxx Crosby, Chandler Jones to thrive, 'He's got all the help he needs': Trey Lance won't have to be savior for loaded San Francisco 49ers, Las Vegas Raiders running backs the 'heartbeat' of the new regime's offensive attack, Mac Jones, Patriots express confidence in 'new offense' despite growing pains, New York Giants likely to buck norm, make safety Xavier McKinney defensive playcaller, Tyquan Thornton shows signs he could end Patriots' early-round WR woes. ET | Fox The Colts, like in previous seasons, are struggling statistically on defense, ranking 31st overall. Matchup rating: 52.4 | Spread: NE -15 (42), What to watch for: Can the Redskins do anything to slow the Patriots' offense? All newly updated picks . The role is great, but don't forget DeAndre Hopkins' suspension has just two weeks left on it. NFL Nation reporters predict the outcomes and scores for Sunday's and Monday's Week 5 games. Matchup rating: 40.4 | Spread: CAR -3.5 (41), What to watch for: Both teams will be relying on top running backs from the 2017 draft to take the pressure off young quarterbacks. Three (Tommy Nobis, 1966; Earl Campbell, 1978; Kenneth Sims, 1982) have been selected first overall. Click on each game for the game preview and CFN Prediction Week 5 NFL Expert Picks MIN-NYG | NYJ-PHI | JAX-CAR Bengals 13, Bills 9 -- Mike Rodak, The Bengals have a tough matchup against one of the league's best defenses (Buffalo is 10th overall), but it looks like their offense finally has begun to click in the past two weeks. The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates . ET | Fox Theres not a whole lot of tape out there on Trubisky, which is a disadvantage for Minnesota in game planning. Atlanta has rushed for at least 179 yards in three of its four games. DiRocco's pick: Panthers 17, Jaguars 16 -- Eric Woodyard. Patrick Mahomes has been as good against the Raiders as any opponent, with a 7-1 record, 22 touchdowns and just three interceptions. Colts 23, 49ers 20 -- Nick Wagoner, The last thing the Colts can do is overlook the 49ers. FPI prediction: SF, 72.5% (by an average of 8.3 points), Matchup must-reads: Chubb's running finally launches Browns' offense How good are first-place 49ers? -- Rich Cimini. Stat to know: Oakland's Darren Waller enters play with 33 receptions, tied for the most by a tight end through the first four games in NFL history (Antonio Gates, 2007). These two teams played last year in similar circumstances, with the Titans leaving with the victory due to Mariota's four touchdowns and a stout running game. NFL Nation reporters give their picks for Week 5, including whether the Cowboys can bounce back against Aaron Rodgers and the Packers. It all culminates with a Monday Night Football matchup between the Raiders and the Chiefs on ESPN. The Giants have had trouble stopping the run, and it could be a problem again this week with Olivier Vernon and Jason Pierre-Paul struggling with injuries. That stat line would be worth 259.6 points, not much different from the 260.1 points that Allen produced last season. Jack Driscoll, who hasn't started a game at left tackle since college, has been getting the work on Hurts' blind side this week. The Rams took their first loss, and the. NE-WSH | BAL-PIT | OAK-CHI Matchup rating: 53.8 | Spread: TEN -3 (38.5), What to watch for: Marcus Mariota has not thrown an interception this season, but the Bills are tied with the Giants and 49ers for second in the NFL with five picks each. Sidney Jones (hamstring) has practiced this week in hopes of playing. So, these teams could have to rely on their defenses. The Steelers' 2022 quarterback journey, and what happens next, What to watch for: The Patriots have given up 325 rushing yards on 51 carries (6.37 on average) over their past six quarters, while the Lions rank first in the NFL in average yards per rush (5.9) and sixth in total rushing yards per game (164). -- Jordan Raanan. That would mean bigger roles for undrafted rookie Keelan Cole (four catches) and recently signed first-year player Max McCaffrey. See Week 5 rankings. Read more. Cowboys' running game will be tested on Sunday (1:06) Herm Edwards and Tedy Bruschi discuss the outcome of what could be a high-scoring game in Dallas. 198 days ago NFL Week 4 of the 2022-23 NFL season has come to a close. They'll be energized, while at home against a tough division rival, and will sneak out another close win. Inside Jets' trade pursuit of Tyreek Hill, and how they rebounded Dolphins say QB Tua Tagovailoa ruled out for Week 5 game vs. New York Jets, What to watch for: Justin Herbert finished with 398 passing yards in the Chargers' win over the Browns last season, the most Cleveland surrendered in any game in 2021. FPI prediction: MIN, 71.6% (by an average of 7.9 points), Matchup must-reads: Jones brings new energy, hope to Giants What's happened to Thielen and Diggs? It wouldn't be a shock if they underestimate the Browns, but they have too many matchups in their favor to lose the game. It prompted Packers coach Matt LaFleur to say this week that defensive coordinator Joe Barry needs to have his players "play more physical" and "in certain situations you might have to put an extra defender in the box." FPI prediction: PHI, 75.9% (by an average of 9.7 points), Matchup must-reads: Jalen Ramsey to the Eagles: What are the realistic odds? Meanwhile, the Cowboys are tied for second in the league with 15 sacks and own the best pass rush win rate in the NFL (56.3%), according to ESPN Metrics powered by NFL Next Gen Stats. -- Paul Gutierrez. Ertz has not scored this season, but his 24 catches rank fourth at the position this season and keep his floor high. Betting nugget: The past four times Jacksonville was a favorite, it lost the game outright, with three of those losses coming against Houston. If that's the case, the Cardinals could pull off the upset. Week 5 NFL game picks: Chiefs top Bills; Cardinals stay perfect with win over 49ers. -- Alaina Getzenberg, Bold prediction: Bills RB Devin Singletary will have his first 100-yard game of the season. Welcome to 2023 NFL draft week. Just ask Tampa Bay Buccaneers fans, or Buffalo Bills fans, or Seattle Seahawks fans, or the defense of the Dallas Cowboys.. -- Mike Reiss, Bold prediction: Lions running back Jamaal Williams will rush for at least two touchdowns.

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